Synthesis of Phosphonoglycine Backbone Units for the Development of Phosphono Peptide Nucleic Acids
نویسندگان
چکیده
منابع مشابه
Backbone modification of nucleic acids: synthesis, structure and therapeutic applications.
Nucleic acids have been extensively modified by replacing the phosphodiester group or the whole sugar phosphodiester with alternative anionic, neutral and cationic structures. Several of these modified oligonucleotides exhibit improved properties including enhanced recognition and binding to RNA, duplex DNA and proteins. This has resulted in the development of new and more potent antisense and ...
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ژورنال
عنوان ژورنال: European Journal of Organic Chemistry
سال: 2013
ISSN: 1434-193X
DOI: 10.1002/ejoc.201300523